Computational Methods in Molecular Biology

Computational Systems Biology Methods in Molecular Biology, Chemistry Biology, Molecular Biomedicine, and Biopharmacy

In the postgenomic era, the large-scale data, such as genome sequences, mRNA sequences, and protein sequences, increase rapidly. It is desired to develop the computational approaches that can derive and analyze useful information from them to promote the development of biomedicine and drug design. Meanwhile, in order to understand how protein-protein interactions and other complex interactions ...

Computational methods in synthetic biology.

We discuss how a theoretical synthetic biology research programme may liberate empiricism in biological sciences beyond the unaided human brain. Because synthetic biological systems are relatively small and largely independent of evolutionary contexts, they can be represented with mathematical models strongly founded on first principles of molecular biology and laws of statistical thermodynamic...

Kernel Methods, Multiclass Classification and Applications to Computational Molecular Biology

Support Vector Machines for pattern recognition were initially conceived for the binary classification case. A common approach to address multi-classification problems with binary classifiers is that of reducing the multiclass problem to a set of binary sub-problems, and combine their predictions in order to obtain a multiclass prediction. Reduction schemes can be represented by Error Correctin...

Computational Molecular Biology

Computational Molecular Biology

Utilization of primary and secondary structure elements to predict a protein's propensity to form amyloids.